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Towards the synthesis of ferrocene nucleic acids

Lydon, Claire Elizabeth (2009)
M.Res. thesis, University of Birmingham.

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Abstract

The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis.

Type of Work:M.Res. thesis.
Supervisor(s):Tucker, James
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Subjects:QD Chemistry
Institution:University of Birmingham
Library Catalogue:Check for printed version of this thesis
ID Code:1248
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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