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Modelling the affinity maturation of B lymphocytes in the germinal centre

Reynolds, Adam Thomas (2010)
M.Phil. thesis, University of Birmingham.

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Abstract

This study involved the successful development of a computer model to simulate the affinity maturation of B lymphocytes in the germinal centre in 3-D because certain behavioural aspects cannot currently be examined experimentally. The software tool recreates the structure of the germinal centre that enables the B cells to move and interact with other cells inside the germinal centre. This allows the modelling of the affinity maturation of the B cells to produce high affinity antibodies. The model was validated against the available published population dynamics data that shows population sizes on different days post-immunisation. The modelling results show a reasonable correspondence with published data. They also suggest that the high affinity plasma cells that are produced from the germinal centre reaction displace the antibodies on the immune complexes on the follicular dendritic cell. This feed-back drives the selection of high affinity centrocytes to be selected and become high affinity plasma blasts and memory B cells. This conclusion has been partially confirmed by recent experimental results (Toellner, unpublished).

Type of Work:M.Phil. thesis.
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:QR Microbiology
Institution:University of Birmingham
ID Code:1080
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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