An investigation into the role of FcRL4\(^+\) B cells in rheumatoid arthritis

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Cameron, James (2019). An investigation into the role of FcRL4\(^+\) B cells in rheumatoid arthritis. University of Birmingham. Ph.D.

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Abstract

Rheumatoid Arthritis (RA) affects approximately 1% of the world population and is associated with pain, fatigue, progressive disability and eventual joint destruction if left untreated. The last decade has revealed the importance of B cells in the pathology of RA through the success of B cell depletion therapy. What has also become clear in recent years is the importance of the microbiota in autoimmunity, with dysbiosis being associated with many conditions, including RA. FcRL4\(^+\) B cells have found in a number of situations of chronic antigenic stimulation and described as having the potential for an intriguing link between innate and adaptive immunity, and between the pathology of the rheumatoid joint and mucosal immunity. This work investigated the presence of FcRL4\(^+\) B cells in the tonsil, the joint of patients with active RA and peripheral blood, and their presence in the age-associated B cell population, with which they share a number of characteristics. The ability of FcRL4\(^+\) B cells to bind IgA was also assessed. Furthermore, the regulation of this population was probed. Finally, the reactivity of monoclonal antibodies, derived from joint resident FcRL4\(^+\) B cells was tested against the human microbiota.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):