TGFβ superfamily signalling in pluripotency and differentiation of human embryonic stem cells

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Chalmantzi, Varvara (2019). TGFβ superfamily signalling in pluripotency and differentiation of human embryonic stem cells. University of Birmingham. Ph.D.

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Abstract

The discovery of human embryonic stem cells (hESCs) 20 years ago (Thomson, 1998), has significantly benefited the field of stem cell biology (Ilic and Ogilvie, 2017). Despite ethical (and legal in some cases) obstacles, therapies utilising hESCs and their derivatives are attempting to tackle several diseases (Ilic and Ogilvie, 2017).

The TGFβ superfamily is known to be implicated in crucial decisions from early development of the embryo to the adult life (Mullen and Wrana, 2017). ACTIVIN A and BMP4 are two members of this superfamily and their activation status has an important impact on hESCs (James, 2005). On the one hand, ACTIVIN A is associated with the maintenance of the undifferentiated state (James et al., 2005), (Beattie et al., 2005), while on the other BMP4 is considered a differentiation stimulus (Xu et al., 2002), (Yu et al., 2011), (Richter et al., 2014).

The aim of this thesis is to study in depth several key cellular responses of hESCs to BMP4 and investigate the role of SARA, a TGFβ signalling mediator (Tsukazaki et al., 1998) in pluripotency and differentiation.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Heath, John KUNSPECIFIEDUNSPECIFIED
Murphy, CarolUNSPECIFIEDUNSPECIFIED
Licence: All rights reserved
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Biosciences
Funders: Medical Research Council
Subjects: Q Science > QH Natural history > QH426 Genetics
URI: http://etheses.bham.ac.uk/id/eprint/9176

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