Behavioural adjuvants to vaccination

Campbell, John P (2010). Behavioural adjuvants to vaccination. University of Birmingham. Ph.D.

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Abstract

This thesis investigated the effects of acute eccentric exercise on the immune response to vaccination in young humans. Study one investigated whether the efficacy of the eccentric exercise intervention was affected by manipulating the timings of exercise prior to influenza vaccination. Three exercise groups were vaccinated immediately, 6 hr or 48 hr after exercise and antibody responses at 28 days post-vaccination were compared to those from a resting control group. All participants exhibited robust antibody responses to the vaccine and no effect of exercise was observed; therefore, it was not possible to determine the effects of exercise timing on vaccine responses. Study two investigated whether the antibody response to influenza vaccination was influenced by the intensity of eccentric exercise. Three groups exercised at an intensity eliciting 60%, 85% or 110% of one repetition maximum, and the antibody responses at 28 days post-vaccination were compared to those from a resting control group. In the exercise groups, both men and women showed enhanced antibody responses against the B/Florida strain, and men had enhanced responses against A/Uruguay, in comparison to resting controls. In both cases, the control group exhibited poorer responses against these strains, but no effect of exercise intensity was observed. Study three investigated whether the site of vaccine administration affected the efficacy of the immune response to hepatitis B vaccination following eccentric exercise. The antibody seroconversion rate to the vaccine was low (approx. 5 %), and thus, further analysis between exercise and control participants was not feasible. In sum, supporting previous research, it appears that acute eccentric exercise can enhance the immune response to poorly immunogenic strains of influenza, but research is needed to establish if exercise can enhance other poorly immunogenic vaccines, or vaccine responses in the immuno-compromised.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Licence:
College/Faculty:	Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department:	School of Sport, Exercise and Rehabilitation Sciences
Funders:	None/not applicable
Subjects:	G Geography. Anthropology. Recreation > GV Recreation Leisure R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
URI:	http://etheses.bham.ac.uk/id/eprint/830

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