Garzon Sanz, Miguel (2016). Developing nucleophilic nitrenoids for the synthesis of complex heterocycles. University of Birmingham. Ph.D.
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GarzonSanz16PhD.pdf
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Abstract
The combination of nucleophilic nitrenoids and gold-catalysis has rapidly emerged as a powerful tool in the assembling of different nitrogen-containing motifs. The research presented in this thesis describes the advances in the field and the exploration of pyrimidium \(N\)-heteroaryl aminides as building blocks in the formation of several fused imidazoheterocycles.
From the initial discovery of this reaction and its application in the synthesis of imidazo[1,2-a]pyrimidines, the scope of this convergent gold-catalysed strategy has been adapted to allow the access to fourteen classes of biologically relevant structures. The proposed mechanism and optimisation will be discussed alongside the accommodation of a wide range of useful functionalities difficult to introduce by other methodologies.
| Type of Work: | Thesis (Doctorates > Ph.D.) | ||||||
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| Award Type: | Doctorates > Ph.D. | ||||||
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| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | ||||||
| School or Department: | School of Chemistry | ||||||
| Funders: | Other | ||||||
| Other Funders: | The University of Birmingham | ||||||
| Subjects: | Q Science > QD Chemistry | ||||||
| URI: | http://etheses.bham.ac.uk/id/eprint/7060 |
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