Organ transplantation related cancer

Desai, Rajeev Ramarao (2016). Organ transplantation related cancer. University of Birmingham. Ph.D.

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Abstract

Cancer is an important cause of mortality among the recipients of organ transplantation. Cancer transmitted from the donors has poor outcome and the fear of such transmission results in non-acceptance of certain organs. Study of the recipients in the UK over 10 years identified 15 cases of transmitted cancers. The rate of cancer transmission was 0.05%.The risk of cancer transmission was 9 times higher from donors older than 45 years. A comparison of the organ donor data with the guidelines classifying the donor’s risk showed that a selected cohort of donors, who are classed as high risk of cancer transmission, could safely donate their organs resulting in valuable additional survival for the recipients, with low risk of cancer transmission. These results provide evidence, for modification of donor classification guidelines resulting in increased availability of safe organs for transplantation. The risk of recurrence after transplantation of cancers treated before transplantation was low in selected recipients undergoing transplantation after a 2 year-wait following the diagnosis of cancer. No association was found between the donor-recipient CMV status and the risk of post-transplant cancer. This research estimated the risk of cancer transmission to the organ transplant recipients enabling improved risk assessment in transplantation.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):