Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol

Takebayashi, Yuiko (2015). Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol. University of Birmingham. Ph.D.

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Abstract

Thiomarinol is a novel hybrid antibiotic produced by \(Pseudoalteromonas\) \(rava\) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Thomas, Chris M.UNSPECIFIEDUNSPECIFIED
Winn, Peter JUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Biosciences
Funders: None/not applicable
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR180 Immunology
URI: http://etheses.bham.ac.uk/id/eprint/5562

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