Idiopathic intracranial hypertension: empowering patients and physicians to advance patient care through research

Mollan, Susan Patricia ORCID: 0000-0002-6314-4437 (2024). Idiopathic intracranial hypertension: empowering patients and physicians to advance patient care through research. University of Birmingham. Ph.D.

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Abstract

Idiopathic Intracranial Hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP), papilloedema, with risk of permanent visual loss and chronic headaches. It predominately affects young women and is associated with obesity. The incidence of IIH is increasing as obesity rates increase, as confirmed in England analysing the Hospital Episode Statistic dataset.

Both physicians and patients are central to improving care and advancing knowledge. The first IIH consensus guidelines brought together a multidisciplinary group. A priority setting partnership was subsequently conducted and found a key knowledge gap that the Idiopathic Intracranial Hypertension Weight Trial (IIHWT) aimed to address.

The IIHWT found that bariatric surgery provided sustained ICP reduction and weight loss for up to two years. The per protocol analysis determined how much body weight should be lost to ensure disease remission. The IIHWT headache analysis uniquely found that ICP was correlated with headache outcomes. The pointwise visual field analysis demonstrated what could be a meaningful change in an IIH trial population.

The direct impact of this work has afforded a change in national guidelines for people living with obesity and IIH. The cumulative knowledge gained has now delivered the first international multidisciplinary research guideline for IIH.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Hill, Lisa J UNSPECIFIED orcid.org/0000-0001-8431-7029 Botfield, Hannah UNSPECIFIED orcid.org/0000-0003-4564-0282 Sinclair, Alexandra UNSPECIFIED orcid.org/0000-0003-2777-5132
Licence:	All rights reserved
College/Faculty:	Colleges (former) > College of Medical & Dental Sciences
School or Department:	Institute of Metabolism and Systems Research
Funders:	None/not applicable
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RE Ophthalmology
URI:	http://etheses.bham.ac.uk/id/eprint/15655

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