Developing a core outcome set for twin pregnancy

Farmer, Nicola (2024). Developing a core outcome set for twin pregnancy. University of Birmingham. M.Sc.

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Abstract

Twin pregnancy is a pregnancy with two fetusus. One in 42 babies are born a twin (1). There are multiple pathophysiological processes that cause twin pregnancy which results in different twin pregnancy types, each attributing an associated risk (2–4). Consequently, mothers and twins are at a significant increased risk of morbidity and mortality (5–7) which has resulted large body of research aiming to improve outcomes for them (8).
In order to provide strong evidence to support the clinical guidance of these patients, research is often combined in the form of meta-analysis. However, this can be hindered by the heterogeneity within outcome reporting in clinical trials. A solution to this, is the use of Core Outcome Set’s (COS). A COS is ‘an agreed standardised collection of outcomes which should be measured and reported as a minimum, in all trials for a specific clinical area’ (9) and are based on what key stakeholders (patients and medical experts) believe are essential for research. A COS for twin pregnancy will therefore standardise outcome reporting in twin pregnancy which will enable data synthesis, ensure future research remains relevant to patients and improve outcomes for mothers and twins.
COS development is broken down into the three distinct stages as defined by The COMET Initiative (9). Stage one is outcome identification, stage two is outcome consensus and stage three is COS finalisation. The aim of this research is to create the initial COS as set out in stages one and two of COS development which will lay the foundation for the final COS for twin pregnancy.

Type of Work:

Thesis (Masters by Research > M.Sc.)

Award Type:

Masters by Research > M.Sc.

Supervisor(s):