Dufficy, Elizabeth Rose Siobhan (2024). The dynamic regulation of PRMTs and their substrates during the DNA damage response. University of Birmingham. Ph.D.
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Dufficy2024PhD.pdf
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Abstract
The dynamic regulation of post-translational modifications (PTMs) during the DNA damage response (DDR) is critical to maintain genomic stability. The importance of arginine methylation in the DDR is becoming increasingly apparent, but how protein arginine methyltransferases (PRMTs) are regulated after DNA damage is still largely unknown. Here, we show that the PRMT5 substrate RUVBL1 is dynamically methylated after IR and olaparib-induced damage. We also characterised a novel PRMT1 substrate USP11, we show that methyl-USP11 regulates DNA end-resectioning by increasing PRMT1-mediated methylation of MRE11.
| Type of Work: | Thesis (Doctorates > Ph.D.) | |||||||||
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| Award Type: | Doctorates > Ph.D. | |||||||||
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| Licence: | All rights reserved | |||||||||
| College/Faculty: | Colleges (former) > College of Medical & Dental Sciences | |||||||||
| School or Department: | Institute of Cancer and Genomic Sciences | |||||||||
| Funders: | Biotechnology and Biological Sciences Research Council | |||||||||
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
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| URI: | http://etheses.bham.ac.uk/id/eprint/14701 |
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