Unravelling the effect of metal ions leaching from bioactive glasses on wound associated biofilms.

Shirgill, Sandeep ORCID: 0000-0001-6910-7592 (2024). Unravelling the effect of metal ions leaching from bioactive glasses on wound associated biofilms. University of Birmingham. Ph.D.

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Abstract

Chronic wounds (principally pressure sores, venous leg ulcers and diabetic foot ulcers) are a drain on global health services and remain a major area of unmet clinical need. Chronic wounds are characterised by a stable and stubborn bacterial biofilm (densely aggregated colonies of bacteria encased by a matrix of extracellular polymeric substances (EPS)) which hinders innate immune response and delays or prevents wound healing. Bioactive glass (BG) fibres doped with antimicrobial metal ions can offer a promising treatment for chronic wound infections.
In this thesis, firstly, an existing partial differential equation (PDE) model of a chronic wound infection is explored and adapted to investigate the combined antibacterial and wound healing effects of metal-doped BG fibres. From solutions, it was observed that the bacterial infection must be eradicated for a chronic wound to heal successfully. Accord- ingly, the development and characterisation of BG fibres doped with the antimicrobial ions, silver and copper, was next considered to investigate their antibacterial/anti-biofilm properties.
Anti-biofilm studies using the bacteria Pseudomonas aeruginosa & Staphylococcus au- reus demonstrated that treatment efficacy depended on the species used. Additionally, treatment was more effective against single-species biofilms compared to dual-species.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Kuehne, Sarah UNSPECIFIED orcid.org/0000-0001-6790-8433 Poologasundarampillai, Gowsihan UNSPECIFIED orcid.org/0000-0002-8498-323X Jabbari, Sara UNSPECIFIED orcid.org/0000-0001-5235-0406 Ward, John UNSPECIFIED orcid.org/0000-0003-0570-2725
Licence:	All rights reserved
College/Faculty:	Colleges (former) > College of Medical & Dental Sciences
School or Department:	School of Dentistry
Funders:	Biotechnology and Biological Sciences Research Council
Subjects:	Q Science > QA Mathematics Q Science > QR Microbiology
URI:	http://etheses.bham.ac.uk/id/eprint/14564

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