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Egan, Ross Thomas 
ORCID: https://orcid.org/0000-0001-7472-8545
(2023).
Bimetallic Triple Helicates: Nucleic Acid Interaction and Functionalization.
University of Birmingham.
Ph.D.
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Egan2023PhD.pdf
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Abstract
This thesis is an exploration into the binding of supramolecular triple helicates to nucleic acids. Ultimately it is hoped that this study can be used to inform further research into controlling this binding.
It begins with a review of biologically available nucleic acid structures and the common characteristics of non-covalent binding drugs. This then follows with a focused review of nucleic acid binding helicates. Chapter 2 introduces a relatively new area of research in the group, namely the rotaxanation of bimetallic helicates. A thiol cleavable rotaxane capping group is applied and then its cleavage is examined with various time dependent methods, showing how helicate DNA binding can be switched off and on again using rotaxanation. Chapters 3 and 4 focus on the binding of helicate enantiomers to nucleic acids. Chapter 3 presents an NMR analysis of a ruthenium cylinder enantiomer to the TAR (Trans Activation Response) RNA hairpin, providing insight into the mechanism and location of binding as well as structural changes to the hairpin on binding. Chapter 4 delves into DNA three-way junction DNA with cylinders, with the aim to understand their binding from the perspective of enantiospecificity. Together they present a picture of the relationship between structure and nucleic acid binding, using enantiospecificity and steric hindrance from macrocycles.
| Type of Work: | Thesis (Doctorates > Ph.D.) | |||||||||
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| Award Type: | Doctorates > Ph.D. | |||||||||
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| Licence: | All rights reserved | |||||||||
| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | |||||||||
| School or Department: | School of Chemistry | |||||||||
| Funders: | Other | |||||||||
| Other Funders: | School of Chemistry Scholarship | |||||||||
| Subjects: | Q Science > QD Chemistry | |||||||||
| URI: | http://etheses.bham.ac.uk/id/eprint/14148 |
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