Assessment of the textural and mouthfeel attributes of ODTs and their importance to patient acceptability

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Asiri, Abdullah (2023). Assessment of the textural and mouthfeel attributes of ODTs and their importance to patient acceptability. University of Birmingham. Ph.D.

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Abstract

The mouthfeel attributes of medicines are important to patient adherence and, therefore, treatment adherence and effectiveness. Presently, there is no standardised criteria for determining mouthfeel acceptability because research in this area is still limited. The work presented in this thesis aims to better understand the physical characteristics and textural attributes of orodispersible tablets (ODTs) and to relate these findings to oral perception during ODTs consumption. A wide range of formulated ODTs, commercially manufactured ODTs and different commercial fillers were assessed regarding their physical characteristics and measured using several instruments. Measurements from the use of the different tools, for example, the texture analyser (TA), have allowed the identification of disintegration, swelling, residue, hardness, and adhesiveness. Textural and physical features are influenced by the balance of ingredients and the choice of the method that is used to manufacture an ODT. These characteristics were also distinguishable between commercially available ODTs and fillers, which may imply variation in mouthfeel and, as a result, acceptability of commercial ODTs. The gold standard approach to assess mouthfeel attributes and patient acceptability is an in vivo sensory examination involving human participants. A sensory study was undertaken using placebo ODTs. Decreased perception of roughness, hardness, stickiness, residue, and dryness are important to improved acceptability. In summary, the TA can be used to identify a range of parameters that impact on the textural and physical features of ODTs. Their identification is worthwhile to know how best to formulate and manufacture ODTs that have an enhanced mouthfeel and patient acceptability.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):