Ultrasound-responsive silica nanoparticles for the delivery of antimicrobial agents in dentistry

Manhota, Menisha (2022). Ultrasound-responsive silica nanoparticles for the delivery of antimicrobial agents in dentistry. University of Birmingham. Ph.D.

Preview

Manhota2022PhD.pdf Text - Accepted Version Available under License All rights reserved. Download (21MB) | Preview

Abstract

Dental infections and diseases are a global health problem. They are caused by the failure to treat and remove biofilms from surfaces in the oral cavity. Current antimicrobial treatments are extensive and ineffective for localised antibiotic delivery to biofilms.
This work describes the first ultrasound-responsive silica nanoparticle (SNP) drug delivery system for antimicrobial agents. The optimised preparation of antimicrobial agent, cetylpyridinium chloride (CPC) has been successfully encapsulated into silica nanoparticles. The drug delivery system has shown promising stability with minimal leakage and enhanced release kinetics when exposed to ultrasonic cavitation, produced from an ultrasonic scaler device used in dentistry.
The CPC⊂SNP nanosystem was further investigated for its antimicrobial activity against Streptococcus sanguinis biofilms. A significant synergistic effect was shown by the combination of CPC⊂SNP and ultrasound compared to CPC alone. Therefore, showing a promising strategy for the localised and controlled delivery of antibiotics.
This proof-of-concept model, lead to the successful encapsulation of the antibiotic, ciprofloxacin (CPX) into SNPs with smaller NP sizes. The CPX⊂SNP nanosystem showed promising US-responsive release and enhanced antimicrobial activity against Streptococcus mutans biofilms compared to larger drug loaded SNPs.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Pikramenou, Zoe UNSPECIFIED UNSPECIFIED Walmsley, Damien UNSPECIFIED UNSPECIFIED Kuehne, Sarah UNSPECIFIED UNSPECIFIED Sammons, Rachel L. UNSPECIFIED UNSPECIFIED
Licence:	All rights reserved
College/Faculty:	Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department:	School of Chemistry
Funders:	Engineering and Physical Sciences Research Council
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RK Dentistry
URI:	http://etheses.bham.ac.uk/id/eprint/13085

Actions

	Request a Correction
	View Item

Downloads