Lydon, Claire Elizabeth (2009). Towards the synthesis of ferrocene nucleic acids. University of Birmingham. M.Res.
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Lydon09MRes.pdf
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Abstract
The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis.
| Type of Work: | Thesis (Masters by Research > M.Res.) | ||||||
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| Award Type: | Masters by Research > M.Res. | ||||||
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| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | ||||||
| School or Department: | School of Chemistry | ||||||
| Funders: | None/not applicable | ||||||
| Subjects: | Q Science > QD Chemistry | ||||||
| URI: | http://etheses.bham.ac.uk/id/eprint/1248 |
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