The Sound of the hallmarks of cancer

Khosravi Mardakheh, Milad ORCID: https://orcid.org/0000-0001-9819-1623 (2022). The Sound of the hallmarks of cancer. University of Birmingham. Ph.D.

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Abstract

The objective of this research is to create a mixed portfolio of data-driven composition and performance interfaces, fixed Electroacoustic/Computer music compositions, and live-improvised musical and audiovisual works reflecting cancer as a disease. The main methodology in generating the raw sonic material is the sonification of high-throughput, protein/RNA fold-change data, derived from the bio- molecular research of cancer cells. This data and relevant insight into the field are obtained as part of a collaboration with Barts Cancer Institute, in London, UK. Furthermore, for the purpose of musical effectiveness and reaching wider audiences, a focus has been placed on balancing the use of data-driven sonic material with composer-driven musical choices, by drawing upon the narrative of the Hallmarks of Cancer (Hanahan and Weinberg, 2011) which is a widely accepted conceptual framework in the field of cancer research for understanding the various biomolecular processes responsible for causing cancer. This method is adopted in order to inspire musical form, and guide some of the syntactic and aesthetic choices within both fixed and improvised works. In addition, this research also reflects upon the use of data sonification as an artistic tool and practice, while also addressing the contradictions and contention that arise as a result of scientific aims and expectations regarding sonification, resulting in a proposed original model for framing and classifying artistic works incorporating this approach.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Mahtani, Annie UNSPECIFIED orcid.org/0000-0001-9064-6312 Wilson, Scott UNSPECIFIED orcid.org/0000-0003-3510-4240
Licence:	All rights reserved Software: Creative Commons: GNU GPL 2.0 Creative Commons: Attribution-Noncommercial 4.0
College/Faculty:	Colleges (2008 onwards) > College of Arts & Law
School or Department:	School of Languages, Cultures, Art History and Music, Department of Music
Funders:	None/not applicable
Subjects:	M Music and Books on Music > M Music Q Science > Q Science (General) T Technology > T Technology (General)
URI:	http://etheses.bham.ac.uk/id/eprint/12237

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