The nutritional profiling of special feeds for phenylketonuria

Daly, Anne ORCID: 0000-0003-2579-8699 (2021). The nutritional profiling of special feeds for phenylketonuria. University of Birmingham. Ph.D.

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Abstract

In children with classical phenylketonuria (PKU), a lifelong low phenylalanine diet is the only treatment option with natural protein (phenylalanine) intake restricted to < 20% of safe recommended intake [1] to minimise neurological damage. The diet must be supplemented with artificial protein or protein substitutes. These are traditionally based on L-amino acids (AA), providing phenylalanine free nitrogen, essential amino acids, tyrosine, vitamins and minerals supporting growth, physiological pathways and protein synthesis. Casein glycomacropeptide (CGMP) is a bioactive sialylated glycophosphopeptide, a derivative from

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):