Luminescent nanoparticles for drug delivery and detection

Haria, Sajni (2021). Luminescent nanoparticles for drug delivery and detection. University of Birmingham. Ph.D.

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Abstract

This thesis shows the design of luminescent nanoparticles that can be used for theranostic applications in nanomedicine, focusing on drug delivery and detection. In this study, two nanoplatform designs are used.

Silica NPs are functionalised with luminescent Ln complexes, whilst simultaneously encapsulating an anticancer drug, in order to monitor drug release. This anticancer drug acts as a light harvesting unit for sensitised Ln luminescence, enabling drug sensing through ‘on and off’ Ln signals. We show the promising use of these NPs as diagnostic tools for drug sensing.

We also report the functionalisation of gold NPs with a dibenzoylmethane molecule attached via thiol bonds, with the ability to bind to Ln ions, and sensitise Ln luminescence.

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Pikramenou, Zoe UNSPECIFIED UNSPECIFIED Hodges, Nikolas UNSPECIFIED UNSPECIFIED
Licence:	All rights reserved
College/Faculty:	Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department:	School of Chemistry
Funders:	Engineering and Physical Sciences Research Council
Subjects:	Q Science > QD Chemistry
URI:	http://etheses.bham.ac.uk/id/eprint/11982

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