The clinical & metabolic correlates of fatigue in inflammatory arthritis & clinically suspect arthralgia

Jutley, Gurpreet Singh ORCID: 0000-0002-6147-5347 (2021). The clinical & metabolic correlates of fatigue in inflammatory arthritis & clinically suspect arthralgia. University of Birmingham. Ph.D.

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Abstract

The earliest stages of inflammatory arthritis are associated with systemic inflammation and a complex set of symptoms including fatigue. Fatigue is common and burdensome. The mechanisms underlying fatigue are not well understood and, as a result, it is not always easy to manage.
Systemic inflammation and metabolic perturbations may play a role in the development of fatigue. A correlation between systemic inflammation and metabolic perturbation has previously been observed in early inflammatory arthritis. While low-density lipoprotein lipids were some of the chief metabolites which contributed to the metabolic signature associated with systemic inflammation, technical limitations in those studies limited their ability to define more broadly other metabolic pathways involved. Given the likely importance of changes in metabolism to the development of fatigue, I set out to further analyse metabolic disturbance in an early arthritis cohort, assessing both sera, filtered to remove interfering high molecular weight species, and urine to provide a broader and clearer picture of the metabolic status of the patients. I have assessed the relationships between metabolic profiles and [1] systemic inflammation and [2] fatigue to shed further light on the drivers of fatigue in early inflammatory arthritis.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):