Precise design and surface modification of poly(ε-caprolactone)-based 2D assemblies

Xia, Tianlai (2021). Precise design and surface modification of poly(ε-caprolactone)-based 2D assemblies. University of Birmingham. M.Sc.

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Abstract

This thesis investigates the precise design of poly(ε-caprolactone)-based 2D assemblies and their selective surface modification.
Chapter One provides a broad introduction of the research, discussing the importance of achieving morphology and size control over nanostructures, polymerisation techniques, self-assembly methods, and surface modification approaches.

Chapter Two demonstrates a controlled fabrication approach of uniform poly(ɛ-caprolactone)-based 2D assemblies utilizing seeded epitaxial crystallisation methods. Exquisite control over the multiblock co-micelles in morphology and dimensions was achieved by altering the amount of added unimers. Moreover, fluorescent labelling was achieved by polymer modification with fluorophores, providing a platform for future applications such as fluorescent imaging or biocompatible and biodegradable carriers.

Chapter Three reports a facile method for the preparation of poly(ε-caprolactone)-based platelets via crystallisation-driven self-assembly (CDSA), in which the height can be finely tuned by in situ photo-RAFT polymerisation. Furthermore, a fluorescent monomer could be synthesised and polymerised on the surface of such platelets allowing confocal microscopic imaging. More importantly, the prepared 2D platelet micelles could be selectively functionalised on the surface with different monomers through selective photo RAFT polymerisation, achieving spatial control over the platelet height. Such strategy has opened the possibility of highly controlled surface functionalisation for soft materials, providing potential applications in material science and polymer chemistry.

Chapter Four summarises the research presented in Chapter Two and Three, providing key conclusions as well as discussing the scope for future directions in this area of research.

Type of Work:

Thesis (Masters by Research > M.Sc.)

Award Type:

Masters by Research > M.Sc.

Supervisor(s):