Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver

Oo, Ye Htun (2010). Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver. University of Birmingham. Ph.D.

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Abstract

The liver is a unique tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by adjusting either hepatic tolerance or mounting immunity against invading pathogens. Thus, it is important to understand the intrahepatic regulatory T cells phenotype and role played by distinct chemokine receptors expressed on regulatory T cells as they are major player in controlling hepatic tolerance. At the same time, it would be crucial to explore the role of new subset of Th17/Tc17 effector lymphocytes characteristic and their positioning in inflamed liver. This thesis demonstrates the crucial role of chemokine receptors in recruitment and positioning of both intrahepatic regulatory T lymphocytes and IL-17 secreting Th17/Tc17 effector lymphocyte in both normal and inflamed human liver.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):