Obstructive sleep apnoea (OSA) in patients with type 1 diabetes (T1D)

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Alshehri, Ziyad Dhafer A. (2020). Obstructive sleep apnoea (OSA) in patients with type 1 diabetes (T1D). University of Birmingham. Ph.D.

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Abstract

There is a high incidence of obstructive sleep apnoea (OSA) in patients with Type 2 diabetes and this is associated with microvascular complications. Despite different aetiology, patients with Type 1 diabetes (T1D) are also at increased risk of diabetes-related vascular complications. Given the lower incidence of T1D, less research has been focussed on it. This research aimed to identify treatable factors which contribute to the morbidity and mortality of T1D. A systematic review, clinical cohort study, and population analysis of GP patient records were conducted to assess the prevalence and development of OSA and associated cardiovascular complications in T1D. This research has shown that OSA is common in T1D and is associated with cardiovascular autonomic neuropathy. It has also shown that T1D increases the incidence of OSA. The main contribution of this study is identifying, for the first time, the risk factors which contribute to the development of OSA in T1D. A further novel finding was that OSA in T1D patients increased the incidence of vascular complications, including heart failure, ischaemic heart disease, peripheral vascular disease, and chronic kidney disease. Better diagnosis and treatment of OSA may help to ameliorate the impact of microvascular complications and heart disease in T1D.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

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