Synthesis of phosphino-triazole ligands

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Zhao, Yiming ORCID: https://orcid.org/0000-0003-2827-6511 (2020). Synthesis of phosphino-triazole ligands. University of Birmingham. Ph.D.

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Abstract

The triazole formation via click chemistry has remained a hot topic in recent years. This thesis disclosed the synthesis of triazole containing phosphine ligand for catalysts work. Chapter 1 gives a brief introduction of click chemistry and usage of triazole in various area. Chapter 2 outlines a synthetic strategy to generate triazole-containing phosphine ligands. These triazole ligands are derived from diaryl or dialkyl phosphine and show good catalytic activity in Suzuki-Miyaura cross-coupling. The relationship between bulkiness and catalytic activity of ligand unveiled by SambVca webtool. Applications of these ligands into lead-like compound preparation has been conducted with satisfactory result. In Chapter 3, phosphine ligands with different number of triazole units are prepared, and the catalytic activity of corresponding ligand-metal complex screened in Suzuki-Miyaura cross-coupling. In addition, corresponding gold complexes of phosphine ligands also been obtained for activity test. Thirteen single-crystal structures were obtained for the bulkiness study of ligand. Chapter 4 has provided three different strategies towards the synthesis of asymmetric version of triazole ligand. And resulting corresponding gold phosphines have been prepared as well for further activity screening.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):