Kolodziej, Adam (2020). Development of an electrochemical platform for the hemofiltration of platinum-based organometallic drugs. University of Birmingham. Ph.D.
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Kolodziej2020PhD.pdf
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Abstract
Cancerous diseases remain a major threat to human population causing millions of deaths every year. Chemotherapy, being a major treatment method, lacks selectivity towards cancerous cells what causes severe side effect in patients who underwent this treatment. Lower quality of life after chemotherapy stimulated research on technologies that could eliminate some of these drawbacks, but no breakthrough has been achieved yet. The overall aim of this project is to develop a novel concept of the electrochemical hemofiltration system for the removal of platinum-based anti-cancer drugs. Since this PhD thesis represents the first approach to develop the electrochemical hemofiltration system, it is mostly composed of systematic studies of aspects that are of key importance for the successful and safe performance of the system.
The thesis is structured is the following way. Chapter 1 introduces a reader to the tackled problem and the state-of-the-art solutions. Chapter 2 presents the aims this thesis is aimed to accomplish. Chapter 3 includes a brief description of experimental techniques that were applied in the research project presents the aims this thesis is aimed to accomplish. Chapter 4 describes the electrochemical behaviour of cisplatin, a common anti-cancer drug, on the surface of gold. Chapter 5 describes factors that determine the stability of sulphur-based modifiers assembled on gold surface. Chapter 6 presents extensive studies on the coordination of cisplatin and other Pt-based molecules in both, homogeneous and heterogeneous phase. Finally, Chapter 7 concludes on the impact this work has on the electrochemical hemofiltration concept along with an insight into future directions of the project.
This thesis provides proof-of-concept experiments that show a great potential of surface-modified electrode in capturing and quantification of Pt-based drugs in physiological medium.
| Type of Work: | Thesis (Doctorates > Ph.D.) | |||||||||
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| Award Type: | Doctorates > Ph.D. | |||||||||
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| Licence: | All rights reserved | |||||||||
| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | |||||||||
| School or Department: | School of Chemistry | |||||||||
| Funders: | Other | |||||||||
| Other Funders: | University of Birmingham | |||||||||
| Subjects: | Q Science > QD Chemistry | |||||||||
| URI: | http://etheses.bham.ac.uk/id/eprint/10306 |
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