Novel prognostic factors in chronic kidney disease

Fenton, Anthony (2020). Novel prognostic factors in chronic kidney disease. University of Birmingham. Ph.D.

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Abstract

Chronic kidney disease (CKD) is a prevalent condition and is associated with an increased risk of serious adverse outcomes, including kidney failure and death. The identification of prognostic factors that improve our ability to predict an individual’s risk of these adverse outcomes and identify potential targets for new treatments could bring significant benefits to the care of patients with CKD. In this work, data and samples from prospective cohort studies of participants with CKD were used to examine four potential prognostic factors: serum free light chains (FLC), urine FLC, monoclonal gammopathy, and serum endotrophin. Serum FLC and endotrophin concentrations were both associated with the risk of death in patients with CKD after adjustment for established prognostic factors, and serum FLC concentration was also independently associated with the risk of kidney failure. Urine FLC and monoclonal gammopathy were not associated with the risk of adverse outcomes. Possible explanations for the identified associations are discussed, as are suggestions for the next steps needed to assess the potential use of these prognostic factors in clinical practice with a view to improving the care of patients with CKD.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):